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KMID : 0357419950250020223
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Korean journal of Virology
1995 Volume.25 No. 2 p.223 ~ p.230
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Achatina fulica Extract Take Decrease Serum p24 Antigen Level in HIV-Infected Individuals
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Abstract
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The role of p24 antigen as a surrogate marker has been limited by the presence of high-titer p24 antibody and antigen-antibody complex in asymptomatic HIV-infected individuals. We used acid treatment method to increase the sensitivity in the
dectection
of p24 antigen in 31 HIV-infected individuals and also it as a tool to evaluate the effect after Achatina fulica Bowdich extract(AFE, 40%)take, The sensitivity by acid treatment in 31 patients increased from 29% to 58%(p<0.001) and absolute level
increased 14-fold. Detection rate of p24 in patients with CD4+ T cells less than 100/ l was 100% and then decreased depending to the increase of CD4+ T cells. During the AFE take, p24 antigen decreased in 13 of 18patients, whereas at 6.2 months
from the
end of AFE take, it increased in all 16 patients(P<0.001). The p24 antigen level decreased 19% during AFE take, but it increased 98% at 6.2 months from the end of take(P<0.001). These data suggest that acid treatment method increases the
detection
of
p24 antigen and AFE take may inhibit HIV replication in vivo.
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KEYWORD
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